Nick asked me to write an article about this, so I will do my best. In this case, the native would have Pisces as the natural ruler of the 12th House. One would have to see in which the planet Neptune was placed to understand more about the native’s mystical and spiritual leanings. Let’s see what would happen if Neptune was placed in the various Houses. I hope this answers Nick’s question. If not, he can ask another 
Neptune’s Placement in the Houses when Pisces is the Sign on the 12th House Cusp
Neptune in the 1st House
The native will wear his mystical and spiritual side on his sleeve. He may have a dreamy and gentle appearance, appearing as he is actually a denizen of the next dimension
Neptune in the 2nd House
This native may make money from a spiritual or mystical pursuit. He may be an alternative healer, such as one who works in the field of energy medicine. Energy medicine includes homeopathy and acupuncture. He may be a hospice worker. He may have a career as an addictions counselor
Neptune in the 3rd House
This native may speak or write about mystical issues. Think of a Wayne Dyer.
Neptune in the 4th House
This native may have a home that is centered on the mystical or spiritual.
Neptune in the 5th
This native may write poems with a spiritual bent or compose or play music with deep spiritual meaning.
Neptune in the 6th
This native will want to be of service in spiritual way such as a massage therapist who deals with the body energies or a homeopath who deals with energy medicine
Neptune in the 7th
This native will want a marriage that has a mystical and spiritual center
Neptune in the 8th
This native will see sex as a deep mystical experience. He would not be likely to have short, superficial relationships
Neptune in the 9th
This native may write or teach about the mystical realm. He may be a Kundalini yoga teacher. He may write books about the next dimension, with such topics as Near Death Experiences.
Neptune in the 10th
This native may have a career as a hospice nurse, a natural healer or an addictions counselor
Neptune in the 11th
This native may bring his love for the mystical world to groups. He may form groups that deal with Near Death Experiences or groups that deal with spiritual issues.
Neptune in the 12th
This native may dream true. He may, also, suffer from depression. He is very sensitive due to the Neptune placement in the 12th House. However, Neptune in the 12th House is in it’s home and hence is the easiest planet to have in the 12th House.
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